Emoxypine Succinate (Mexidol), ≥98%

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Emoxipine and its succinate salt are chemical compounds with antioxidant and membrane-protective properties. In Russia, they have been reported as antidepressant agents. (The product is for research purposes only.)

Chemical Name2-ethyl-6-methyl-3-hydroxypyridine succinate
SynonymsEmoxipine succinate, Emoxypin succinate, Mexidol, Mexidole, Emicidine, Epigid, 2-Ethyl-6-methylpyridin-3-ol succinate, 6-Methyl-2-ethyl-3-hydroxypyridine succinate, 2-Ethyl-6-methyl-3-pyridinol succinate
CAS #127464-43-1
FormWhite to pale cream powder.
Molecular FormulaC8H11NO • C4H6O4
Molecular Weight255.27 g/mol
SolubilityHighly soluble in water.

 

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Precaution and Disclaimer:

This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

Chemical Information

CAS Number:127464-43-1
Purity:≥98%
Molecular Weight:255.27 g/mol
Melting Point:113°C
Molecular Formula:C8H11NO • C4H6O4
Synonyms:Emoxipine succinate, Emoxypin succinate, Mexidol, Mexidole, Emicidine, Epigid, 2-Ethyl-6-methylpyridin-3-ol succinate, 6-Methyl-2-ethyl-3-hydroxypyridine succinate, 2-Ethyl-6-methyl-3-pyridinol succinate
PubChem CID:122298
SMILES:CCC1=C(C=CC(=N1)C)O.C(CC(=O)O)C(=O)O

Technical Information

Application:Emoxipine and its succinate salt are chemical compounds with antioxidant and membrane-protective properties. In Russia, they have been reported as antidepressant agents. (This product is for research purposes only.)
Appearance:White to pale cream powder
Physical State:Solid
Solubility:Highly soluble in water.
Storage:Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability:Stable for at least two years when stored as above.

Biochemical Activity

Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine)[1] , also known as Mexidol or Mexifin when used as the succinate salt, is an antioxidant.Its chemical structure resembles that of pyridoxine (a type of vitamin B). It is not approved for any medical use in the United States or Europe.

In Russia, emoxypine succinate has a wide range of applications in medical practice. Emoxypine has been reported to improve cerebral blood circulation, inhibit thrombocyte aggregation, lower cholesterol levels, and to have cardioprotective and antiatherosclerotic action. It is reported to exert anxiolytic, anti-stress, anti-alcohol, anticonvulsant, nootropic, neuroprotective and anti-inflammatory action.[4] [5]

Emoxypine's mechanism of action is believed to be its antioxidant and membrane-protective effects, claimed to be based upon the following key biochemical properties:[6]

  • Emoxypine inhibits free radical oxidation of biomembrane lipids, reacts to peroxide radicals of lipids and primary and hydroxyl radicals of peptides
  • Emoxypine increases the activity of antioxidant enzymes, specifically that of superoxide dismutase, responsible for the safe inactivation of lipid peroxides and active oxygen forms
  • Emoxypine inhibits free radicals during the synthesis of prostaglandins catalyzed by cyclooxygenase and lipoxygenase, increases the correlation of prostacyclin / thromboxane A2, and blocks leukotriene formation
  • Emoxypine increases the content of polar fraction of lipids (phosphatidyl serine and phosphatidyl inositol) and reduces the cholesterol/phospholipid ratio which provides its lipid-regulatory properties; promotes the reduction of membrane viscosity and the increase of membrane fluidity, increases the lipid-protein ratio.
  • Modulates the activity of membrane-bound enzymes: phosphodiesterase, cyclic nucleotides, adenylate cyclase, aldoreductase, acetylcholinesterase.
  • Modulates the receptor complexes of the brain membranes, i.e. benzodiazepine, GABA, acetylcholine receptors by increasing their binding ability.
  • Stabilizes biomembranes, i.e. membrane structures of blood cells - erythrocytes and thrombocytes during their haemolysis or mechanical injury accompanied by the formation of free radicals.
  • Changes monoamine levels and increases the dopamine content in the brain.
Clinical study

One study determined the effectiveness of emoxypine in 205 patients with clinical manifestations of lumbosacral radiculopathy (LSR). Patients were divided into two groups, and further were divided into subgroups depending on the presence of motor disturbances. All patients received a course of conventional medical treatment and physiotherapy; main group additionally received emoxypine. Thereafter, clinical-neurological control of long-term results of treatment in subgroups of patients was performed. The results showed that the use of emoxypine in the combined therapy of patients with LSR led to significant and persistent reduction of severity of pain syndrome and rapid recovery of function of spinal roots and peripheral nerves compared with conventional therapy.[5][7]

References

  • [1] W. Gruber, (1953) 31(6): 564-568, "Synthesis of 3- Hydroxy-2-Alkylpyridines" doi:10.1139/v53-079
  • [4] Volchegorskii, I.A., Miroshnichenko, I.Y., Rassokhina, L.M. et al. Bull Exp Biol Med (2015) 158: 756. doi:10.1007/s10517-015-2855-3
  • [5] Rumyantseva, S.A., Fedin, A.I. & Sokhova, O.N. Neurosci Behav Physi (2012) 42: 842. doi:10.1007/s11055-012-9646-3
  • [6] Dumayev K.M., Voronina T.A., Smirnov L.D. antioxidants in the prophylaxis and therapy of CNS pathologies
  • [7] Likhacheva EB, Sholomov II, 2006;106(10):52-7 "Zh Nevrol Psikhiatr Im S S Korsakova" PMID:17117675

Precaution and Disclaimer:

This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

[Emoxypine Q1 2018] Emoxypine.12112001.pdf

[Emoxypine Q2 2017] Emoxypine.17030601.pdf