Picamilon sodium, ≥98%
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Picamilon is a molecule formed by an amide linkage of the vitamin Niacin (vitamin B3, nicotinic acid) with the inhibitory neurotransmitter GABA
Chemical Name | 4-(Pyridine-3-carbonylamino)butanoic acid sodium salt |
CAS Number | 62936-56-5 |
Purity | ≥98% |
Form | White or off-white powder |
Molecular Weight | 230.20 g/mol |
Melting Point | 208.0-212.0°C |
Molecular Formula | C10H11N2O3 •Na |
Synonyms | Picamilon, Pikamilone sodium salt, Pikamilone, Pikamilon sodium salt, Nicotinoyl-GABA sodium salt, Monosodium 4-(pyridine-3-carbonylamino)butanoate, Monosodium 4-Nicotinoylaminobutyrate, N-(3-Pyridinylcarbonyl)-4-aminobutyric acid sodium |
Precaution and Disclaimer:
This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.
Chemical Information:
CAS Number: | 62936-56-5 |
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Purity: | ≥98% |
Molecular Weight: | 230.20 g/mol |
Melting Point: | 208.0-212.0°C |
Molecular Formula: | C10H11N2O3 •Na |
Synonyms: | Picamilon, Pikamilone sodium salt, Pikamilone, Pikamilon sodium salt, Nicotinoyl-GABA sodium salt, 4-(Pyridine-3-carbonylamino)butanoic acid sodium salt, Monosodium 4-(pyridine-3-carbonylamino)butanoate, Monosodium 4-Nicotinoylaminobutyrate, N-(3-Pyridinylcarbonyl)-4-aminobutyric acid sodium |
PubChem CID: | 23663986 |
SMILES: | C1=CC(=CN=C1)C(=O)NCCCC(=O)[O-].[Na+] |
Technical Information:
Application: | Picamilon is a linked derivative of the vitamin Niacin (vitamin B3, nicotinic acid) with the inhibitory neurotransmitter GABA, useful in the research of BBB penetrant molecules which hydrolyse to yield GABA. |
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Appearance: | White or off-white powder |
Physical State: | Solid |
Solubility: | Freely soluble in Ethanol, Water. |
Storage: | Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity. |
Stability: | Stable for at least two years when stored as above. |
Biochemical Activity:
Picamilon is a amide derivative of the vitamin Niacin (vitamin B3, nicotinic acid) and the inhibitory neurotransmitter GABA. It was developed in the Soviet Union in 1969[1] and further studied in both Russia[2] and Japan as a prodrug of GABA.[3],[4],[5]
References:
- [1] Kopelevich VM, Gunar VI (April 1999). "Some approaches to the directed search for new drugs based on nicotinic acid". Pharmaceutical Chemistry Journal 33 (4): 177–187. doi:10.1007/BF02509934
- [2] Mirzoian RS, Gan'shina TS (1989). "[The new cerebrovascular preparation pikamilon]". Farmakologiia i Toksikologiia (in Russian) 52 (1): 23–6. PMID 2707413
- [3] Matsuyama K, Yamashita C, Noda A, Goto S, Noda H, Ichimaru Y, Gomita Y (Oct 1984). "Evaluation of isonicotinoyl-gamma-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA". Chemical & Pharmaceutical Bulletin 32 (10): 4089–95. doi:10.1248/cpb.32.4089. PMID 6529802
- [4] Dorofeev BF, Kholodov LE (1991). "[Pikamilon pharmacokinetics in animals]". Farmakologiia i Toksikologiia (in Russian) 54 (2): 66-9. PMID 1884802
- [5] Cui W, Chen X, Zhan Y, Zhang Z, Zhang Y, Zhong D (2010). "Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 878 (15-16): 1181–4. doi: 10.1016/j.jchromb.2010.03.013. PMID 20359966
Precaution and Disclaimer:
This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.
[Picamilon Sodium Q3 2018] Picamilon.Sodium.18060501.pdf