Picamilon sodium, ≥98%

PICAMILON SODIUM ≥98%

Chemical Name:     4-(Pyridine-3-carbonylamino)butanoic acid sodium salt
CAS Number:    62936-56-5
Purity:    ≥98%
Form:    White or off-white powder
Molecular Weight:    230.20 g/mol
Melting Point:    208.0-212.0°C
Molecular Formula:    C10H11N2O3 •Na
Synonyms:     Picamilon, Pikamilone sodium salt, Pikamilone, Pikamilon sodium salt, Nicotinoyl-GABA sodium salt, Monosodium 4-(pyridine-3-carbonylamino)butanoate, Monosodium 4-Nicotinoylaminobutyrate, N-(3-Pyridinylcarbonyl)-4-aminobutyric acid sodium


Picamilon is a molecule formed by an amide linkage of the vitamin Niacin (vitamin B3, nicotinic acid) with the inhibitory neurotransmitter GABA

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Chemical Information:

CAS Number:62936-56-5
Purity:≥98%
Molecular Weight:230.20 g/mol
Melting Point:208.0-212.0°C
Molecular Formula:C10H11N2O3 •Na
Synonyms: Picamilon, Pikamilone sodium salt, Pikamilone, Pikamilon sodium salt, Nicotinoyl-GABA sodium salt, 4-(Pyridine-3-carbonylamino)butanoic acid sodium salt, Monosodium 4-(pyridine-3-carbonylamino)butanoate, Monosodium 4-Nicotinoylaminobutyrate, N-(3-Pyridinylcarbonyl)-4-aminobutyric acid sodium
PubChem CID:23663986
SMILES:C1=CC(=CN=C1)C(=O)NCCCC(=O)[O-].[Na+]

Technical Information:

Application:Picamilon is a linked derivative of the vitamin Niacin (vitamin B3, nicotinic acid) with the inhibitory neurotransmitter GABA, useful in the research of BBB penetrant molecules which hydrolyse to yield GABA.
Appearance:White or off-white powder
Physical State:Solid
Solubility:Freely soluble in Ethanol, Water.
Storage:Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability:Stable for at least two years when stored as above.

Biochemical Activity:

Picamilon is a amide derivative of the vitamin Niacin (vitamin B3, nicotinic acid) and the inhibitory neurotransmitter GABA. It was developed in the Soviet Union in 1969[1] and further studied in both Russia[2] and Japan as a prodrug of GABA.[3],[4],[5]

References:

  • [1] Kopelevich VM, Gunar VI (April 1999). "Some approaches to the directed search for new drugs based on nicotinic acid". Pharmaceutical Chemistry Journal 33 (4): 177–187. doi:10.1007/BF02509934
  • [2] Mirzoian RS, Gan'shina TS (1989). "[The new cerebrovascular preparation pikamilon]". Farmakologiia i Toksikologiia (in Russian) 52 (1): 23–6. PMID 2707413
  • [3] Matsuyama K, Yamashita C, Noda A, Goto S, Noda H, Ichimaru Y, Gomita Y (Oct 1984). "Evaluation of isonicotinoyl-gamma-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA". Chemical & Pharmaceutical Bulletin 32 (10): 4089–95. doi:10.1248/cpb.32.4089. PMID 6529802
  • [4] Dorofeev BF, Kholodov LE (1991). "[Pikamilon pharmacokinetics in animals]". Farmakologiia i Toksikologiia (in Russian) 54 (2): 66-9. PMID 1884802
  • [5] Cui W, Chen X, Zhan Y, Zhang Z, Zhang Y, Zhong D (2010). "Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 878 (15-16): 1181–4. doi: 10.1016/j.jchromb.2010.03.013. PMID 20359966

Precaution and Disclaimer:

This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

[Picamilon Sodium Q3 2018] Picamilon.Sodium.18060501.pdf