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Picamilon is a linked derivative of the vitamin Niacin (vitamin B3, nicotinic acid) with the inhibitory neurotransmitter GABA, useful in the research of BBB penetrant molecules which hydrolyse to yield GABA.
White or off-white powder
Freely soluble in Ethanol, Water.
Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stable for at least two years when stored as above.
Picamilon is a amide derivative of the vitamin Niacin (vitamin B3, nicotinic acid) and the inhibitory neurotransmitter GABA. It was developed in the Soviet Union in 1969 and further studied in both Russia and Japan as a prodrug of GABA.,,
 Kopelevich VM, Gunar VI (April 1999). "Some approaches to the directed search for new drugs based on nicotinic acid". Pharmaceutical Chemistry Journal 33 (4): 177–187. doi:10.1007/BF02509934
 Mirzoian RS, Gan'shina TS (1989). "[The new cerebrovascular preparation pikamilon]". Farmakologiia i Toksikologiia (in Russian) 52 (1): 23–6. PMID 2707413
 Matsuyama K, Yamashita C, Noda A, Goto S, Noda H, Ichimaru Y, Gomita Y (Oct 1984). "Evaluation of isonicotinoyl-gamma-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA". Chemical & Pharmaceutical Bulletin 32 (10): 4089–95. doi:10.1248/cpb.32.4089. PMID 6529802
 Dorofeev BF, Kholodov LE (1991). "[Pikamilon pharmacokinetics in animals]". Farmakologiia i Toksikologiia (in Russian) 54 (2): 66-9. PMID 1884802
 Cui W, Chen X, Zhan Y, Zhang Z, Zhang Y, Zhong D (2010). "Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 878 (15-16): 1181–4. doi: 10.1016/j.jchromb.2010.03.013. PMID 20359966
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This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.